| 1 |
ICV391 |
22.24 | 66.72% | 33.33% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=2.7µM) |
| 2 |
ICV439 |
22.01 | 47% | 46.84% |
human: "Na, K-exchanging ATPase pump" | NA | MERS(IC=0.08µM) Vero |
| 3 |
ICV289 |
21.32 | 43.79% | 48.68% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=8µM) |
| 4 |
ICV287 |
19.05 | 45.3% | 42.05% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=20.1µM) |
| 5 |
ICV290 |
18.87 | 38.76% | 48.68% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=9.1µM) |
| 6 |
ICV401 |
15.98 | 71.93% | 22.22% |
virus: RNA-directed RNA polymerase L | P26676 | MERS(EC50=9.99µM) Vero cell; SARS-CoV-2(EC50=109.5) Vero E6 |
| 7 |
ICV389 |
15.59 | 69.62% | 22.4% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=3µM) |
| 8 |
ICV398 |
14.21 | 76.39% | 18.6% |
virus: RNA-dependent RNA polymerase | P0DTD1 | polymerase extension experiments |
| 9 |
ICV410 |
14.04 | 31.98% | 43.9% |
human: "Ca, Na,-exchanging ATPase pump" | NA | MERS(IC=0.16µM) Vero |
| 10 |
ICV411 |
13.96 | 31.8% | 43.9% |
human: "Ca, Na,-exchanging ATPase pump" | NA | MERS(IC=0.17µM) Vero |
| 11 |
ICV399 |
12.26 | 72% | 17.02% |
virus: RNA-dependent RNA polymerase | P0DTD1 | polymerase extension experiments |
| 12 |
ICV390 |
11.92 | 66.85% | 17.83% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=7µM) |
| 13 |
ICV144 |
11.35 | 55.2% | 20.56% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=42.79µM) |
| 14 |
ICV153 |
10.55 | 52.77% | 20% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=10µM) |
| 15 |
ICV428 |
10.48 | 43.67% | 24% |
human: Eukaryotic initiation factor 4A-I | P60842 | MERS(EC50=3nM) MRC-5 cell; HCoV-229E(EC50=1.3nM) MRC-5 cell |
| 16 |
ICV145 |
10.05 | 48.89% | 20.56% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=24.14µM) |
| 17 |
ICV288 |
9.42 | 46.44% | 20.29% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=12.3µM) |
| 18 |
ICV286 |
9.4 | 52.4% | 17.95% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=7.8µM) |
| 19 |
ICV392 |
8.9 | 51.89% | 17.16% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=5.4µM) |
| 20 |
ICV150 |
8.76 | 52.04% | 16.84% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=5.5µM) |
