| 1 |
ICV245 |
35.44 | 88.11% | 40.22% |
virus: 3C-like protease | P0DTD1 | 95.32% inhibition ratio at 1mM |
| 2 |
ICV246 |
30.66 | 89.92% | 34.09% |
virus: 3C-like protease | P0DTD1 | 95.37% inhibition ratio at 1mM |
| 3 |
ICV241 |
30.05 | 90.17% | 33.33% |
virus: 3C-like protease | P0DTD1 | 86.73% inhibition ratio at 1mM |
| 4 |
ICV409 |
29.56 | 75.16% | 39.33% |
human: ATP synthase | NA | MERS(IC=0.55µM) Vero |
| 5 |
ICV243 |
29.07 | 89.21% | 32.58% |
virus: 3C-like protease | P0DTD1 | 82.55% inhibition ratio at 1mM |
| 6 |
ICV240 |
28.92 | 89.75% | 32.22% |
virus: 3C-like protease | P0DTD1 | 90.54% inhibition ratio at 1mM |
| 7 |
ICV242 |
28.2 | 89.47% | 31.52% |
virus: 3C-like protease | P0DTD1 | 84.17% inhibition ratio at 1mM |
| 8 |
ICV244 |
24.84 | 88.23% | 28.16% |
virus: 3C-like protease | P0DTD1 | 93.96% inhibition ratio at 1mM |
| 9 |
ICV197 |
22.68 | 76.36% | 29.7% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=18.2µM) |
| 10 |
ICV358 |
21.15 | 57.09% | 37.04% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=2.6µM); SARS(EC50=13.1µM) Vero E6; SARS-CoV-2(IC50=5µM) |
| 11 |
ICV307 |
20.37 | 64.04% | 31.82% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=24.8µM) |
| 12 |
ICV305 |
20.18 | 63.42% | 31.82% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=46.1µM) |
| 13 |
ICV425 |
19.92 | 66.88% | 29.79% |
human: Dopamine receptor | NA | MERS(EC50=2.5µM) Huh7 cell |
| 14 |
ICV432 |
18.82 | 61.84% | 30.43% |
human: Histamine N-methyltransferase | P50135 | MERS-CoV(EC50=2.1µM) |
| 15 |
ICV332 |
17.57 | 47.44% | 37.04% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=5.7µM) |
| 16 |
ICV333 |
17.34 | 49.71% | 34.88% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=0.39µM) |
| 17 |
ICV308 |
17.19 | 61.39% | 28% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=11.1µM) |
| 18 |
ICV355 |
16.89 | 49.55% | 34.09% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50<50µM) |
| 19 |
ICV357 |
16.81 | 60.04% | 28% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=0.6µM); SARS (EC50=14.5µM) Vero E6;SARS-CoV-2(IC50=2.4µM) |
| 20 |
ICV254 |
16.64 | 73% | 22.79% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=12.66µM) |
