| 1 |
ICV127(covalent) |
18.97 | 64.21% | 29.55% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=40µM) |
| 2 |
ICV266 |
15.31 | 68.91% | 22.22% |
virus: 3C-like protease | P0DTD1 | SARS-CoV-2 3CL(IC50=1.82µM) |
| 3 |
ICV103 |
15.04 | 41.77% | 36% |
virus: 3C-like protease | P0DTD1 | SARS 3CL R188I mutant protease(IC50=37µM) |
| 4 |
ICV396 |
14.59 | 72.94% | 20% |
virus: RNA-dependent RNA polymerase | P0DTD1 | SARS-CoV-2(EC50=95.96µM) Vero E6 |
| 5 |
ICV434 |
14.58 | 74.5% | 19.57% |
human: Matrix protein 2 | P21430 | SARS(EC50=8-16µg,ml) fRhK4 |
| 6 |
ICV153 |
14.56 | 54.36% | 26.79% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=10µM) |
| 7 |
ICV269 |
13.99 | 47.9% | 29.21% |
virus: 3C-like protease | P0DTD1 | SARS-CoV-2 3CL(IC50=4.13µM) |
| 8 |
ICV23(covalent) |
13.5 | 49.81% | 27.1% |
virus: 3C-like protease | P0DTD1 | SARS recombinant 3CL or 3CL(IC50=3.48µM) |
| 9 |
ICV328 |
13.44 | 52.08% | 25.81% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=1.9µM) |
| 10 |
ICV398 |
13.19 | 77.42% | 17.04% |
virus: RNA-dependent RNA polymerase | P0DTD1 | polymerase extension experiments |
| 11 |
ICV314 |
13.04 | 55.25% | 23.6% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=30µM) |
| 12 |
ICV324 |
13 | 51.36% | 25.32% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=2.2µM) |
| 13 |
ICV270 |
12.95 | 53.12% | 24.39% |
virus: 3C-like protease | P0DTD1 | SARS-CoV-2 3CL(IC50=0.97µM) |
| 14 |
ICV327 |
12.49 | 48.39% | 25.81% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=18µM) |
| 15 |
ICV40(covalent) |
12.44 | 42.3% | 29.41% |
virus: 3C-like protease | P0DTD1 | MERS 3CL(IC50=0.6µM); SARS 3CL(IC50=2.1µM); FIPV(IC50=0.8µM) |
| 16 |
ICV326 |
12.35 | 48.76% | 25.32% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=12.7µM) |
| 17 |
ICV313 |
12 | 49.73% | 24.14% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=59.2µM) |
| 18 |
ICV325 |
11.92 | 47.08% | 25.32% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=13.5µM) |
| 19 |
ICV345 |
11.86 | 56.31% | 21.05% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=18.3µM) |
| 20 |
ICV167 |
11.79 | 65.26% | 18.06% |
virus: 3C-like protease | P0DTD1 | HCoV-229E(EC50=1.34µM) MRC5 |
