| 1 |
ICV293 |
29.68 | 61.65% | 48.15% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=5.7µM) |
| 2 |
ICV426 |
28.17 | 75.55% | 37.29% |
human: Estrogen receptor | P03372 | MERS(EC50=10.117µM) Vero E6; SARS(EC50=92.886µM) Vero E6 |
| 3 |
ICV377 |
27.22 | 76.36% | 35.65% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=61.9µM); MERS 3CL(IC50=33.9µM); MERS PL(IC50=82.2µM) |
| 4 |
ICV17 |
27.02 | 56.89% | 47.5% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=65µM) |
| 5 |
ICV58 |
25.41 | 54.25% | 46.84% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=10µM); SARS(ec50=0.11µM) Vero E6 |
| 6 |
ICV59 |
25.22 | 52.4% | 48.13% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=7µM); SARS(ec50=0.16µM) Vero E6 |
| 7 |
ICV291 |
24.9 | 65.3% | 38.14% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=6.2µM) |
| 8 |
ICV368 |
24.15 | 63.52% | 38.02% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=88.1µM); MERS 3CL(IC50=36.2µM); MERS PL(IC50=42.1µM) |
| 9 |
ICV367 |
23.45 | 69.21% | 33.88% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=57.8µM); MERS 3CL(IC50=27.9µM); MERS PL(IC50=112.9µM) |
| 10 |
ICV303 |
23.39 | 77.33% | 30.25% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=13.5µM) |
| 11 |
ICV201 |
22.77 | 63.46% | 35.88% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=77.09µM) |
| 12 |
ICV154 |
22.54 | 65.07% | 34.64% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=25µM) |
| 13 |
ICV5(covalent) |
21.57 | 61.92% | 34.84% |
virus: 3C-like protease | P0DTD1 | MERS 3CL(IC50=2.4µM); SARS 3CL(IC50=0.7µM) |
| 14 |
ICV302 |
21.45 | 70.32% | 30.51% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=90µM) |
| 15 |
ICV369 |
21.33 | 64% | 33.33% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=202.7µM); MERS 3CL(IC50=193.7µM); MERS PL(IC50=171.6µM) |
| 16 |
ICV77 |
21 | 55.07% | 38.13% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=10µM); SARS(EC50=6.44µM) Vero E6 |
| 17 |
ICV315 |
20.75 | 67.58% | 30.71% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=1.21µM); SARS(EC50=11.6µM) Vero E6 |
| 18 |
ICV56 |
20.67 | 56.26% | 36.75% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=5µM); SARS(ec50=9.45µM) Vero E6 |
| 19 |
ICV68 |
20.53 | 65.25% | 31.47% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=4.92µM); HCoV-229E 3CL(IC50=4.68µM) |
| 20 |
ICV194 |
20.53 | 74.75% | 27.46% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=23.5µM) |
