Target Detail

Citrate lyase subunit beta-like protein, mitochondrial

Abbreviation: CLYBL

Uniprot id / Protein id:Q8N0X4

Organism:human

Mechanism:CLYBL converts the immune modulatory TCA cycle metabolite itaconate through the citramalyl-CoA intermediate to acetyl-CoA, an increase in CLYBL may lead to the depletion of itaconate, limiting its anti-inflammatory function

Reference (PMID or DOI):35290573

Model Source:PDB

Template PDB_ID:5vxc

Pockets:There are 5 pockets in Citrate lyase subunit beta-like protein, mitochondrial.
pocket 1:

pocket 2:

pocket 3:

pocket 4:

pocket 5:

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