Target Detail

ORF1ab polyprotein 819-2763 Papain-like proteinase

Abbreviation: PLP/PLpro
State: Monomer

Uniprot id / Protein id:QHD43415.1


Mechanism:PLP is responsible for the cleavage of non-structural proteins (nsp) 1, 2 and 3. In addition, PLP can deubiquitinate or deISGylate host cell proteins, resulting in the immune suppression of host cells.

Reference (PMID or DOI):20181693, 19369340

Model Source:Swiss-model

Template PDB_ID:3e9s

Sequence Identity:82.86%

Pockets:There are 6 pockets in ORF1ab polyprotein 819-2763 Papain-like proteinase.
pocket 1:

pocket 2:

pocket 3:

pocket 4:

pocket 5:

pocket 6:

This site has been visited 3723483 times since Feb 2020.