Target Detail

ORF1ab polyprotein 6799-7096 2'-O-methyltransferase

Abbreviation: 2'-O-Mtase

Uniprot id / Protein id:QHD43415.1


Mechanism:2'-O-Mtase can mediate mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral mRNAs which is essential to evade immune system.

Reference (PMID or DOI):21637813, 18417574

Model Source:Swiss-model

Template PDB_ID:2xyr

Sequence Identity:93.49%

Pockets:There are 5 pockets in ORF1ab polyprotein 6799-7096 2'-O-methyltransferase.
pocket 1:

pocket 2:

pocket 3:

pocket 4:

pocket 5:

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