Target Detail

cGMP-specific 3',5'-cyclic phosphodiesterase

Abbreviation: PDE5

Uniprot id / Protein id:O76074

Organism:human

Mechanism:PDEs is responsible for the degradation of cAMP, which may aggravate the virus-induced pulmonary fibrosis.

Reference (PMID or DOI):10.1101/2020.02.27.20027557

Model Source:PDB

Template PDB_ID:2h44

Pockets:There are 10 pockets in cGMP-specific 3',5'-cyclic phosphodiesterase.
pocket 1:

pocket 2:

pocket 3:

pocket 4:

pocket 5:

pocket 6:

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pocket 9:

pocket 10:

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