D3DistalMutation

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D3DistalMutation ( >10Å )

DistalMutation ( >10Å )

Mutation ( <10Å )

loss of activity

Enzyme Name	Abbreviation	Uniprot ID	PDB ID	PDB Chain	Mutation Resi	Mutation Type	Active Site Resi	Active Resn	dist (Å)	Activity Change	References
(2Z,6E)-farnesyl diphosphate synthase	Rv1086	P9WFF5	2vfw	A	107	V->G	40,89	D,N	12.62	No detectable activity.	18597781
(2Z,6E)-farnesyl diphosphate synthase	Rv1086	P9WFF5	2vfw	B	107	V->G	40,89	D,N	12.37	No detectable activity.	18597781
(2Z,6E)-farnesyl diphosphate synthase	Rv1086	P9WFF5	2vg0	A	107	V->G	40,89	D,N	12.14	No detectable activity.	18597781
(2Z,6E)-farnesyl diphosphate synthase	Rv1086	P9WFF5	2vg0	B	107	V->G	40,89	D,N	12.06	No detectable activity.	18597781
(2Z,6E)-farnesyl diphosphate synthase	Rv1086	P9WFF5	2vg1	A	107	V->G	40,89	D,N	12.28	No detectable activity.	18597781
(2Z,6E)-farnesyl diphosphate synthase	Rv1086	P9WFF5	2vg1	B	107	V->G	40,89	D,N	12.77	No detectable activity.	18597781
(S)-8-oxocitronellyl enol synthase	ISY	K7WDL7	5emh	A	342	F->A	146,178	K,Y	27.93	Abolishes enzymatic activity.	26768532
1,3-beta-galactosyl-N-acetylhexosamine phosphorylase	lnpA	E8MF13	2zuw	C	362	Y->N	313	D	10.69	Lack of activity.	19124470
1,3-beta-galactosyl-N-acetylhexosamine phosphorylase	lnpA	E8MF13	3wfz	A	362	Y->N	313	D	10.19	Lack of activity.	19124470
1,3-beta-galactosyl-N-acetylhexosamine phosphorylase	lnpA	E8MF13	3wfz	B	362	Y->N	313	D	10.24	Lack of activity.	19124470
1,3-beta-galactosyl-N-acetylhexosamine phosphorylase	lnpA	E8MF13	3wfz	D	362	Y->N	313	D	10.29	Lack of activity.	19124470
1,3-beta-galactosyl-N-acetylhexosamine phosphorylase	lnpA	E8MF13	2zuu	C	32	R->E	313	D	10.21	Lack of activity.	19124470
1,3-beta-galactosyl-N-acetylhexosamine phosphorylase	lnpA	E8MF13	3wfz	B	32	R->E	313	D	10.58	Lack of activity.	19124470
1,3-beta-galactosyl-N-acetylhexosamine phosphorylase	lnpA	E8MF13	3wfz	C	32	R->E	313	D	10	Lack of activity.	19124470
1,3-beta-galactosyl-N-acetylhexosamine phosphorylase	lnpA	E8MF13	2zus	A	362	Y->N	313	D	10.12	Lack of activity.	19124470
1,3-beta-galactosyl-N-acetylhexosamine phosphorylase	lnpA	E8MF13	2zus	B	362	Y->N	313	D	10.37	Lack of activity.	19124470
1,3-beta-galactosyl-N-acetylhexosamine phosphorylase	lnpA	E8MF13	2zus	C	362	Y->N	313	D	10.07	Lack of activity.	19124470
1,3-beta-galactosyl-N-acetylhexosamine phosphorylase	lnpA	E8MF13	2zus	D	362	Y->N	313	D	10.32	Lack of activity.	19124470
1,3-beta-galactosyl-N-acetylhexosamine phosphorylase	lnpA	E8MF13	2zut	A	362	Y->N	313	D	10.29	Lack of activity.	19124470
1,3-beta-galactosyl-N-acetylhexosamine phosphorylase	lnpA	E8MF13	2zut	B	362	Y->N	313	D	10.99	Lack of activity.	19124470
1,3-beta-galactosyl-N-acetylhexosamine phosphorylase	lnpA	E8MF13	2zut	C	362	Y->N	313	D	10.95	Lack of activity.	19124470
1,3-beta-galactosyl-N-acetylhexosamine phosphorylase	lnpA	E8MF13	2zut	D	362	Y->N	313	D	10.53	Lack of activity.	19124470
1,3-beta-galactosyl-N-acetylhexosamine phosphorylase	lnpA	E8MF13	2zuu	A	362	Y->N	313	D	10.01	Lack of activity.	19124470
1,3-beta-galactosyl-N-acetylhexosamine phosphorylase	lnpA	E8MF13	2zuu	B	362	Y->N	313	D	10.87	Lack of activity.	19124470
1,3-beta-galactosyl-N-acetylhexosamine phosphorylase	lnpA	E8MF13	2zuu	C	362	Y->N	313	D	10.67	Lack of activity.	19124470

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D3DistalMutation ( >10Å )

DistalMutation ( >10Å )

Mutation ( <10Å )

loss of activity