D3DistalMutation

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D3DistalMutation ( >10Å )

DistalMutation ( >10Å )

Mutation ( <10Å )

Multiple/Deletion Mutation

Enzyme Name	Abbreviation	Uniprot ID	PDB ID	PDB Chain	Mutation Resi	Mutation Type	Active Site Resi	Active Resn	dist (Å)	Activity Change	References
3-oxoacyl-[acyl-carrier-protein] reductase FabG1	FabG1	P9WGT3	1uzl	A	60	C->V	153	Y	15.1	Totally inactive; when associated with A-139 and L-144.	17642518
3-oxoacyl-[acyl-carrier-protein] reductase FabG1	FabG1	P9WGT3	1uzl	B	60	C->V	153	Y	15.2	Totally inactive; when associated with A-139 and L-144.	17642518
3-oxoacyl-[acyl-carrier-protein] reductase FabG1	FabG1	P9WGT3	1uzm	A	60	C->V	153	Y	15.19	Totally inactive; when associated with A-139 and L-144.	17642518
3-oxoacyl-[acyl-carrier-protein] reductase FabG1	FabG1	P9WGT3	1uzm	B	60	C->V	153	Y	14.88	Totally inactive; when associated with A-139 and L-144.	17642518
3-oxoacyl-[acyl-carrier-protein] reductase FabG1	FabG1	P9WGT3	1uzn	A	60	C->V	153	Y	16.58	Totally inactive; when associated with A-139 and L-144.	17642518
3-oxoacyl-[acyl-carrier-protein] reductase FabG1	FabG1	P9WGT3	1uzn	B	60	C->V	153	Y	16.23	Totally inactive; when associated with A-139 and L-144.	17642518
3-oxoacyl-[acyl-carrier-protein] reductase FabG1	FabG1	P9WGT3	2ntn	A	60	C->V	153	Y	15.36	Totally inactive; when associated with A-139 and L-144.	17642518
3-oxoacyl-[acyl-carrier-protein] reductase FabG1	FabG1	P9WGT3	2ntn	B	60	C->V	153	Y	15.23	Totally inactive; when associated with A-139 and L-144.	17642518
4-hydroxy-tetrahydrodipicolinate synthase	HTPA synthase	Q9X1K9	1o5k	A	166-168	DID->AAA	132,161	Y,K	10.97	Decreased activity and substrate affinity.	21803176
4-hydroxy-tetrahydrodipicolinate synthase	HTPA synthase	Q9X1K9	1o5k	B	166-168	DID->AAA	132,161	Y,K	11.06	Decreased activity and substrate affinity.	21803176
4-hydroxy-tetrahydrodipicolinate synthase	HTPA synthase	Q9X1K9	3pb0	A	166-168	DID->AAA	132,161	Y,K	11.05	Decreased activity and substrate affinity.	21803176
4-hydroxy-tetrahydrodipicolinate synthase	HTPA synthase	Q9X1K9	3pb0	B	166-168	DID->AAA	132,161	Y,K	11.08	Decreased activity and substrate affinity.	21803176
4-hydroxy-tetrahydrodipicolinate synthase	HTPA synthase	Q9X1K9	3pb0	C	166-168	DID->AAA	132,161	Y,K	11.01	Decreased activity and substrate affinity.	21803176
4-hydroxy-tetrahydrodipicolinate synthase	HTPA synthase	Q9X1K9	3pb0	D	166-168	DID->AAA	132,161	Y,K	11.17	Decreased activity and substrate affinity.	21803176
4-hydroxy-tetrahydrodipicolinate synthase	HTPA synthase	Q9X1K9	3pb2	A	166-168	DID->AAA	132,161	Y,K	10.99	Decreased activity and substrate affinity.	21803176
4-hydroxy-tetrahydrodipicolinate synthase	HTPA synthase	Q9X1K9	3pb2	B	166-168	DID->AAA	132,161	Y,K	11.15	Decreased activity and substrate affinity.	21803176
4-hydroxy-tetrahydrodipicolinate synthase	HTPA synthase	Q9X1K9	3pb2	C	166-168	DID->AAA	132,161	Y,K	10.92	Decreased activity and substrate affinity.	21803176
4-hydroxy-tetrahydrodipicolinate synthase	HTPA synthase	Q9X1K9	3pb2	D	166-168	DID->AAA	132,161	Y,K	11.06	Decreased activity and substrate affinity.	21803176
4-hydroxy-tetrahydrodipicolinate synthase	HTPA synthase	Q9X1K9	3pb2	E	166-168	DID->AAA	132,161	Y,K	11	Decreased activity and substrate affinity.	21803176
4-hydroxy-tetrahydrodipicolinate synthase	HTPA synthase	Q9X1K9	3pb2	F	166-168	DID->AAA	132,161	Y,K	11.07	Decreased activity and substrate affinity.	21803176
ATP-dependent Clp protease proteolytic subunit, mitochondrial	CLPP	Q16740	1tg6	A	58-61	Missing	153,178	S,H	24.81	Abolishes protease activity.	15522782
ATP-dependent Clp protease proteolytic subunit, mitochondrial	CLPP	Q16740	1tg6	B	58-61	Missing	153,178	S,H	22.57	Abolishes protease activity.	15522782
ATP-dependent Clp protease proteolytic subunit, mitochondrial	CLPP	Q16740	1tg6	C	58-61	Missing	153,178	S,H	23.02	Abolishes protease activity.	15522782
ATP-dependent Clp protease proteolytic subunit, mitochondrial	CLPP	Q16740	1tg6	D	58-61	Missing	153,178	S,H	20.4	Abolishes protease activity.	15522782
ATP-dependent Clp protease proteolytic subunit, mitochondrial	CLPP	Q16740	1tg6	E	58-61	Missing	153,178	S,H	23.53	Abolishes protease activity.	15522782

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D3DistalMutation ( >10Å )

DistalMutation ( >10Å )

Mutation ( <10Å )

Multiple/Deletion Mutation