Welcome to D3EGFR

欢迎使用 D3EGFR

D3EGFR is a webserver for drug sensitivity retrieval and deep learning-guided drug sensitivity prediction of EGFR mutation-driven lung cancer.




As the key oncogenic drivers in non-small cell lung cancer (NSCLC), various mutations of epidermal growth factor receptor (EGFR) with variable drug sensitivities have been the major obstacle for personalized medicine. A platform for drug sensitivity retrieval and reliable drug sensitivity prediction is desired for physician-scientists and clinicians. For the purpose, we built a database, namely D3EGFRdb, with the information of a total of 1,158 patients harboring EGFR mutations. Besides, we developed a deep learning model, namely D3EGFRAI, for drug sensitivity prediction for EGFR mutation-driven NSCLC. Accordingly, we constructed a web server, namely D3EGFR, to provide drug response retrieval through existing patient cases with specific clinical information and outcomes, and to predict drug response for patients harboring either common or rare or newly identified EGFR mutations.