| 1 |
ICV73 |
22.84 | 61% | 37.45% |
virus: 3C-like protease | P0DTD1 | Replicon (BHK) (IC50=2µM); SARS(IC50=8.9µM) Vero |
| 2 |
ICV72 |
21.64 | 56.8% | 38.1% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=2.5µM) |
| 3 |
ICV412 |
20.16 | 56.54% | 35.66% |
human: Calcium channel | NA | MERS(IC=2.36µM) Vero |
| 4 |
ICV413 |
19.34 | 51.37% | 37.65% |
human: Calcium channel | NA | MERS(IC=4.07µM) Vero |
| 5 |
ICV78 |
18.88 | 63.63% | 29.67% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=39µM) |
| 6 |
ICV200 |
18.64 | 55.93% | 33.33% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=101.38µM) |
| 7 |
ICV58 |
18.56 | 62.29% | 29.8% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=10µM); SARS(ec50=0.11µM) Vero E6 |
| 8 |
ICV442 |
17.64 | 54.46% | 32.38% |
human: 50S ribosomal protein L2 | P20276 | MERS(EC50=0.0718µM) Vero E6 |
| 9 |
ICV279 |
17.41 | 66.95% | 26% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=9.5µM) |
| 10 |
ICV49 |
17.29 | 60.76% | 28.46% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=85µM) |
| 11 |
ICV440 |
17.29 | 55.67% | 31.06% |
human: Synaptic Vesicular amine transporter | Q05940 | SARS(EC50=3.4µM) Vero E6 |
| 12 |
ICV71(covalent) |
17.27 | 54.45% | 31.72% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(Kinact=0.0025,min) |
| 13 |
ICV280 |
17.26 | 66.89% | 25.81% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=9.2µM) |
| 14 |
ICV439 |
17.26 | 60.86% | 28.36% |
human: "Na, K-exchanging ATPase pump" | NA | MERS(IC=0.08µM) Vero |
| 15 |
ICV77 |
17.23 | 58.34% | 29.54% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=10µM); SARS(EC50=6.44µM) Vero E6 |
| 16 |
ICV3(covalent) |
17.12 | 58.07% | 29.48% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=15µM) |
| 17 |
ICV392 |
17 | 65.57% | 25.93% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=5.4µM) |
| 18 |
ICV284 |
16.93 | 67.7% | 25% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=10.4µM) |
| 19 |
ICV292 |
16.8 | 56.31% | 29.84% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=59.8µM) |
| 20 |
ICV154 |
16.75 | 48.47% | 34.56% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=25µM) |
