| 1 |
ICV371 |
35.71 | 68.94% | 51.8% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=30.2µM); MERS 3CL(IC50=34.7µM); MERS PL(IC50=48.8µM) |
| 2 |
ICV373 |
31.72 | 65.3% | 48.57% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=233.3µM); MERS PL(IC50=94.9µM) |
| 3 |
ICV374 |
31.33 | 64.97% | 48.21% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=92.4µM); MERS 3CL(IC50=125.7µM); MERS PL(IC50=49.1µM) |
| 4 |
ICV372 |
30.27 | 61.36% | 49.33% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=84.8µM); MERS PL(IC50=88.5µM) |
| 5 |
ICV275 |
29.21 | 65.1% | 44.87% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=6.2µM) |
| 6 |
ICV299 |
29 | 65.45% | 44.31% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=5µM) |
| 7 |
ICV276 |
28.64 | 64.23% | 44.59% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=6.1µM) |
| 8 |
ICV277 |
28.57 | 64.38% | 44.38% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=11.6µM) |
| 9 |
ICV280 |
28.27 | 65.59% | 43.1% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=9.2µM) |
| 10 |
ICV376 |
25.35 | 62.02% | 40.88% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=64.2µM); MERS 3CL(IC50=109.2µM); MERS PL(IC50=55µM) |
| 11 |
ICV282 |
25.32 | 58.38% | 43.37% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=12.7µM) |
| 12 |
ICV279 |
24.61 | 57% | 43.18% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=9.5µM) |
| 13 |
ICV426 |
24.07 | 59.95% | 40.15% |
human: Estrogen receptor | P03372 | MERS(EC50=10.117µM) Vero E6; SARS(EC50=92.886µM) Vero E6 |
| 14 |
ICV206 |
24.02 | 60.93% | 39.43% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(EC50=23µM) |
| 15 |
ICV285 |
23.84 | 55.19% | 43.2% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=13.9µM) |
| 16 |
ICV427 |
23.64 | 63.34% | 37.32% |
human: Estrogen receptor | P03372 | MERS(EC50=12.915µM) Vero E6; SARS(EC50=11.969µM) Vero E6 |
| 17 |
ICV281 |
22.88 | 52.66% | 43.45% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=13.2µM) |
| 18 |
ICV284 |
22.87 | 52.42% | 43.64% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=10.4µM) |
| 19 |
ICV428 |
22.78 | 56.65% | 40.21% |
human: Eukaryotic initiation factor 4A-I | P60842 | MERS(EC50=3nM) MRC-5 cell; HCoV-229E(EC50=1.3nM) MRC-5 cell |
| 20 |
ICV278 |
22.72 | 50.88% | 44.65% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=12.5µM) |
