| 1 |
ICV153 |
53.03 | 75.76% | 70% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=10µM) |
| 2 |
ICV149 |
20.99 | 73.46% | 28.57% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=10.3µM) |
| 3 |
ICV150 |
19.93 | 75.75% | 26.32% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=5.5µM) |
| 4 |
ICV286 |
19.42 | 63.64% | 30.51% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=7.8µM) |
| 5 |
ICV151 |
18.39 | 80.48% | 22.86% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=9.9µM) |
| 6 |
ICV434 |
15.38 | 61.53% | 25% |
human: Matrix protein 2 | P21430 | SARS(EC50=8-16µg,ml) fRhK4 |
| 7 |
ICV288 |
15.02 | 70.1% | 21.43% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=12.3µM) |
| 8 |
ICV439 |
13.62 | 62.81% | 21.69% |
human: "Na, K-exchanging ATPase pump" | NA | MERS(IC=0.08µM) Vero |
| 9 |
ICV438 |
13.49 | 75.04% | 17.98% |
human: Na channel | NA | MERS(IC=3.6µM) Vero |
| 10 |
ICV152 |
13.27 | 78.52% | 16.9% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=2.6µM) |
| 11 |
ICV287 |
13.17 | 63.06% | 20.88% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=20.1µM) |
| 12 |
ICV410 |
11.92 | 56.27% | 21.18% |
human: "Ca, Na,-exchanging ATPase pump" | NA | MERS(IC=0.16µM) Vero |
| 13 |
ICV275 |
11.3 | 76.44% | 14.78% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=6.2µM) |
| 14 |
ICV411 |
10.95 | 51.71% | 21.18% |
human: "Ca, Na,-exchanging ATPase pump" | NA | MERS(IC=0.17µM) Vero |
| 15 |
ICV276 |
10.78 | 73.58% | 14.66% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=6.1µM) |
| 16 |
ICV103 |
10.47 | 61.1% | 17.14% |
virus: 3C-like protease | P0DTD1 | SARS 3CL R188I mutant protease(IC50=37µM) |
| 17 |
ICV127(covalent) |
10.43 | 71.26% | 14.63% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=40µM) |
| 18 |
ICV391 |
10.41 | 70.46% | 14.77% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=2.7µM) |
| 19 |
ICV289 |
9.98 | 65.24% | 15.29% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=8µM) |
| 20 |
ICV277 |
9.73 | 68.67% | 14.17% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=11.6µM) |
