| 1 |
ICV176 |
25.97 | 73.36% | 35.4% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=0.31µM) |
| 2 |
ICV302 |
25.44 | 62.43% | 40.74% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=90µM) |
| 3 |
ICV189 |
25.37 | 72.94% | 34.78% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=0.03µM) |
| 4 |
ICV175 |
24.61 | 66.46% | 37.04% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=0.03µM) |
| 5 |
ICV245 |
21.24 | 81.41% | 26.09% |
virus: 3C-like protease | P0DTD1 | 95.32% inhibition ratio at 1mM |
| 6 |
ICV369 |
19.93 | 61.95% | 32.17% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=202.7µM); MERS 3CL(IC50=193.7µM); MERS PL(IC50=171.6µM) |
| 7 |
ICV283 |
19.18 | 57.07% | 33.6% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=14.4µM) |
| 8 |
ICV178 |
19.14 | 70.01% | 27.34% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=0.5µM) |
| 9 |
ICV303 |
19 | 53.84% | 35.29% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=13.5µM) |
| 10 |
ICV391 |
18.75 | 69.64% | 26.92% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=2.7µM) |
| 11 |
ICV377 |
18.34 | 63.48% | 28.89% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=61.9µM); MERS 3CL(IC50=33.9µM); MERS PL(IC50=82.2µM) |
| 12 |
ICV275 |
18.29 | 52.69% | 34.71% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=6.2µM) |
| 13 |
ICV129 |
18.07 | 64.01% | 28.23% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(Ki=45.8µM) |
| 14 |
ICV206 |
17.96 | 63.3% | 28.37% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(EC50=23µM) |
| 15 |
ICV276 |
17.52 | 50.88% | 34.43% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=6.1µM) |
| 16 |
ICV426 |
17.3 | 60.86% | 28.42% |
human: Estrogen receptor | P03372 | MERS(EC50=10.117µM) Vero E6; SARS(EC50=92.886µM) Vero E6 |
| 17 |
ICV284 |
17.15 | 53.9% | 31.82% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=10.4µM) |
| 18 |
ICV130 |
17.11 | 62.74% | 27.27% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(Ki=35.3µM) |
| 19 |
ICV367 |
16.97 | 59.7% | 28.42% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=57.8µM); MERS 3CL(IC50=27.9µM); MERS PL(IC50=112.9µM) |
| 20 |
ICV409 |
16.96 | 67.85% | 25% |
human: ATP synthase | NA | MERS(IC=0.55µM) Vero |
