| 1 |
ICV127(covalent) |
42.81 | 73.13% | 58.54% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=40µM) |
| 2 |
ICV23(covalent) |
39.73 | 68.11% | 58.33% |
virus: 3C-like protease | P0DTD1 | SARS recombinant 3CL or 3CL(IC50=3.48µM) |
| 3 |
ICV40(covalent) |
33.73 | 55.41% | 60.87% |
virus: 3C-like protease | P0DTD1 | MERS 3CL(IC50=0.6µM); SARS 3CL(IC50=2.1µM); FIPV(IC50=0.8µM) |
| 4 |
ICV22 |
32.5 | 59.3% | 54.81% |
virus: 3C-like protease | P0DTD1 | SARS recombinant 3CL or 3CL(IC50=4.66µM) |
| 5 |
ICV41(covalent) |
25.86 | 53.1% | 48.7% |
virus: 3C-like protease | P0DTD1 | MERS 3CL(IC50=0.8µM); SARS 3CL(IC50=5.2µM); FIPV 3CL(IC50=1.6µM) |
| 6 |
ICV69(covalent) |
25.18 | 52.57% | 47.9% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(Ki=0.053µM); HCoV-229E 3CL(Ki=0.068µM); HCoV-229E(IC50=0.14µM) MRC-5;SARS(IC50=0.6µM) Vero E6 |
| 7 |
ICV104 |
24.52 | 52.16% | 47.01% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(Ki=21µM) |
| 8 |
ICV125(covalent) |
24.39 | 60.97% | 40% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=15µM) |
| 9 |
ICV42(covalent) |
24.28 | 57.24% | 42.42% |
virus: 3C-like protease | P0DTD1 | MERS 3CL(IC50=0.7µM); SARS 3CL(IC50=3.9µM); FIPV 3CL(IC50=0.8µM) |
| 10 |
ICV415 |
23.9 | 62.61% | 38.18% |
human: Calpain | NA | SARS(EC50=0.5µM) Vero 76 |
| 11 |
ICV21(covalent) |
23.72 | 62.38% | 38.03% |
virus: 3C-like protease | P0DTD1 | SARS recombinant 3CL or 3CL(IC50=4.35µM); SARS-CoV-2 3CL(IC50=0.03µM) |
| 12 |
ICV324 |
22.43 | 69.7% | 32.18% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=2.2µM) |
| 13 |
ICV39(covalent) |
22.13 | 56.14% | 39.42% |
virus: 3C-like protease | P0DTD1 | MERS 3CL(IC50=0.4µM); SARS 3CL(IC50=5.1µM); FIPV 3CL(IC50=2.4µM) |
| 14 |
ICV79 |
22.12 | 57.01% | 38.81% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(Ki=0.66µM); HCoV-229E(IC50=9.1µM) MRC-5 |
| 15 |
ICV271 |
21.74 | 61.15% | 35.56% |
virus: 3C-like protease | P0DTD1 | SARS-CoV-2 3CL(IC50=0.45µM) |
| 16 |
ICV270 |
21.63 | 72.9% | 29.67% |
virus: 3C-like protease | P0DTD1 | SARS-CoV-2 3CL(IC50=0.97µM) |
| 17 |
ICV103 |
21.59 | 51.19% | 42.17% |
virus: 3C-like protease | P0DTD1 | SARS 3CL R188I mutant protease(IC50=37µM) |
| 18 |
ICV269 |
21.35 | 58.56% | 36.46% |
virus: 3C-like protease | P0DTD1 | SARS-CoV-2 3CL(IC50=4.13µM) |
| 19 |
ICV24(covalent) |
20.86 | 59.09% | 35.29% |
virus: 3C-like protease | P0DTD1 | MERS(EC50=0.5µM) |
| 20 |
ICV52 |
20.4 | 52.51% | 38.85% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=38µM) |
