| 1 |
ICV439 |
29.33 | 57.5% | 51% |
human: "Na, K-exchanging ATPase pump" | NA | MERS(IC=0.08µM) Vero |
| 2 |
ICV287 |
25.86 | 48.03% | 53.85% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=20.1µM) |
| 3 |
ICV289 |
24.35 | 52.34% | 46.53% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=8µM) |
| 4 |
ICV290 |
23.45 | 50.39% | 46.53% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=9.1µM) |
| 5 |
ICV391 |
22.21 | 70.94% | 31.3% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=2.7µM) |
| 6 |
ICV410 |
21.7 | 43.4% | 50% |
human: "Ca, Na,-exchanging ATPase pump" | NA | MERS(IC=0.16µM) Vero |
| 7 |
ICV428 |
21.3 | 59.86% | 35.58% |
human: Eukaryotic initiation factor 4A-I | P60842 | MERS(EC50=3nM) MRC-5 cell; HCoV-229E(EC50=1.3nM) MRC-5 cell |
| 8 |
ICV411 |
18.5 | 37.01% | 50% |
human: "Ca, Na,-exchanging ATPase pump" | NA | MERS(IC=0.17µM) Vero |
| 9 |
ICV389 |
18.1 | 76.43% | 23.68% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=3µM) |
| 10 |
ICV390 |
16.79 | 77.91% | 21.55% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=7µM) |
| 11 |
ICV73 |
16.28 | 65.83% | 24.73% |
virus: 3C-like protease | P0DTD1 | Replicon (BHK) (IC50=2µM); SARS(IC50=8.9µM) Vero |
| 12 |
ICV153 |
15.78 | 63.9% | 24.69% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=10µM) |
| 13 |
ICV144 |
14.74 | 62.63% | 23.53% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=42.79µM) |
| 14 |
ICV72 |
14.6 | 65.36% | 22.34% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=2.5µM) |
| 15 |
ICV154 |
14.38 | 63.87% | 22.52% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=25µM) |
| 16 |
ICV442 |
14.16 | 58.02% | 24.41% |
human: 50S ribosomal protein L2 | P20276 | MERS(EC50=0.0718µM) Vero E6 |
| 17 |
ICV145 |
14.12 | 60.01% | 23.53% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=24.14µM) |
| 18 |
ICV401 |
14.02 | 68.77% | 20.38% |
virus: RNA-directed RNA polymerase L | P26676 | MERS(EC50=9.99µM) Vero cell; SARS-CoV-2(EC50=109.5) Vero E6 |
| 19 |
ICV286 |
13.62 | 52.9% | 25.74% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=7.8µM) |
| 20 |
ICV150 |
13.54 | 59.7% | 22.69% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=5.5µM) |
