| 1 |
ICV440 |
20.45 | 72.53% | 28.2% |
human: Synaptic Vesicular amine transporter | Q05940 | SARS(EC50=3.4µM) Vero E6 |
| 2 |
ICV401 |
18.46 | 53.95% | 34.22% |
virus: RNA-directed RNA polymerase L | P26676 | MERS(EC50=9.99µM) Vero cell; SARS-CoV-2(EC50=109.5) Vero E6 |
| 3 |
ICV405 |
18.41 | 68.77% | 26.76% |
human: ABL1 pathway | NA | MERS(EC50=5.468µM) Vero E6; SARS(EC50=2.1µM) Vero E6 |
| 4 |
ICV398 |
18.25 | 58.23% | 31.34% |
virus: RNA-dependent RNA polymerase | P0DTD1 | polymerase extension experiments |
| 5 |
ICV436 |
18.01 | 69.77% | 25.81% |
human: MEK1,2 | NA | NA |
| 6 |
ICV202 |
16.65 | 65.96% | 25.25% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=90.72µM) |
| 7 |
ICV30 |
16.48 | 71.49% | 23.06% |
virus: 3C-like protease | P0DTD1 | MERS 3CL(IC50=10.1µM); SARS 3CL(IC50=20.2µM) |
| 8 |
ICV392 |
16.45 | 64.18% | 25.63% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=5.4µM) |
| 9 |
ICV403 |
16.35 | 55.83% | 29.28% |
virus: Envelope protein; Spike protein | QHD43418.1,P0DTC2 | FIPV(EC50=7.8µM) Black TN406HP |
| 10 |
ICV34 |
16.3 | 73.05% | 22.31% |
virus: 3C-like protease | P0DTD1 | MERS 3CL(IC50=9.6µM); SARS 3CL(IC50=18.7µM) |
| 11 |
ICV433 |
16.13 | 59.22% | 27.24% |
human: Lanosterol 14-alpha demethylase(Yeast) | P10613 | MERS(EC50=12.203µM) Vero E6; SARS(EC50=15.327µM) Vero E6 |
| 12 |
ICV399 |
15.89 | 50.6% | 31.41% |
virus: RNA-dependent RNA polymerase | P0DTD1 | polymerase extension experiments |
| 13 |
ICV197 |
15.81 | 62.06% | 25.48% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=18.2µM) |
| 14 |
ICV29 |
15.77 | 69.23% | 22.77% |
virus: 3C-like protease | P0DTD1 | MERS 3CL(IC50=12.2µM); SARS 3CL(IC50=16.4µM) |
| 15 |
ICV397 |
15.6 | 56.43% | 27.65% |
virus: RNA-dependent RNA polymerase | P0DTD1 | SARS-CoV-2(EC50=0.77µM) Vero E6 |
| 16 |
ICV28 |
15.59 | 65.02% | 23.97% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=44.7µM) |
| 17 |
ICV431 |
15.4 | 62.89% | 24.48% |
human: Histamine H1 receptor | P35367 | MERS(EC50=4.884µM) Vero E6; SARS(EC50=5.591µM) Vero E6 |
| 18 |
ICV142 |
15.27 | 72% | 21.2% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=1.69µM) |
| 19 |
ICV31 |
15.2 | 70.81% | 21.47% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=37.5µM) |
| 20 |
ICV27 |
15.11 | 71.4% | 21.16% |
virus: 3C-like protease | P0DTD1 | MERS 3CL(IC50=30.3µM); SARS 3CL(IC50=41.2µM) |
