| 1 |
ICV401 |
100 | 100% | 100% |
virus: RNA-directed RNA polymerase L | P26676 | MERS(EC50=9.99µM) Vero cell; SARS-CoV-2(EC50=109.5) Vero E6 |
| 2 |
ICV399 |
25.9 | 78.12% | 33.15% |
virus: RNA-dependent RNA polymerase | P0DTD1 | polymerase extension experiments |
| 3 |
ICV398 |
25.51 | 76.97% | 33.14% |
virus: RNA-dependent RNA polymerase | P0DTD1 | polymerase extension experiments |
| 4 |
ICV389 |
17.12 | 77.84% | 21.99% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=3µM) |
| 5 |
ICV390 |
16.19 | 75.11% | 21.56% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=7µM) |
| 6 |
ICV396 |
15.23 | 77.56% | 19.64% |
virus: RNA-dependent RNA polymerase | P0DTD1 | SARS-CoV-2(EC50=95.96µM) Vero E6 |
| 7 |
ICV391 |
15.18 | 80.81% | 18.79% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=2.7µM) |
| 8 |
ICV433 |
14.15 | 52.55% | 26.92% |
human: Lanosterol 14-alpha demethylase(Yeast) | P10613 | MERS(EC50=12.203µM) Vero E6; SARS(EC50=15.327µM) Vero E6 |
| 9 |
ICV266 |
13.82 | 74.81% | 18.48% |
virus: 3C-like protease | P0DTD1 | SARS-CoV-2 3CL(IC50=1.82µM) |
| 10 |
ICV386 |
13.75 | 68.42% | 20.1% |
virus: Helicase | P0DTD1 | MERS-CoV Helicase activity(IC50=4.3µM) |
| 11 |
ICV254 |
13.55 | 82.07% | 16.51% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=12.66µM) |
| 12 |
ICV260 |
13.41 | 79.37% | 16.9% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=9.91µM) |
| 13 |
ICV197 |
13.38 | 74.83% | 17.88% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=18.2µM) |
| 14 |
ICV382 |
13.31 | 68.8% | 19.34% |
virus: Helicase | P0DTD1 | MERS-CoV Helicase activity(IC50=5.7µM) |
| 15 |
ICV387 |
13.3 | 68.1% | 19.52% |
virus: Helicase | P0DTD1 | MERS-CoV Helicase activity(IC50=2.5µM) |
| 16 |
ICV392 |
13.2 | 60.18% | 21.93% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=5.4µM) |
| 17 |
ICV383 |
13 | 68.59% | 18.96% |
virus: Helicase | P0DTD1 | MERS-CoV Helicase activity(IC50=3µM) |
| 18 |
ICV127(covalent) |
12.81 | 67.9% | 18.87% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=40µM) |
| 19 |
ICV385 |
12.68 | 68.28% | 18.57% |
virus: Helicase | P0DTD1 | MERS-CoV Helicase activity(IC50=6.3µM) |
| 20 |
ICV384 |
12.57 | 68.66% | 18.31% |
virus: Helicase | P0DTD1 | MERS-CoV Helicase activity(IC50=9µM) |
