| 1 |
ICV397 |
36.5 | 50.25% | 72.63% |
virus: RNA-dependent RNA polymerase | P0DTD1 | SARS-CoV-2(EC50=0.77µM) Vero E6 |
| 2 |
ICV440 |
22.22 | 61.84% | 35.92% |
human: Synaptic Vesicular amine transporter | Q05940 | SARS(EC50=3.4µM) Vero E6 |
| 3 |
ICV392 |
21.68 | 65.97% | 32.86% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=5.4µM) |
| 4 |
ICV202 |
19.93 | 73.03% | 27.3% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=90.72µM) |
| 5 |
ICV389 |
18.25 | 65.66% | 27.8% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=3µM) |
| 6 |
ICV436 |
17.7 | 70.39% | 25.15% |
human: MEK1,2 | NA | NA |
| 7 |
ICV390 |
16.93 | 67.26% | 25.17% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=7µM) |
| 8 |
ICV431 |
16.85 | 63.84% | 26.39% |
human: Histamine H1 receptor | P35367 | MERS(EC50=4.884µM) Vero E6; SARS(EC50=5.591µM) Vero E6 |
| 9 |
ICV73 |
16.78 | 69.45% | 24.16% |
virus: 3C-like protease | P0DTD1 | Replicon (BHK) (IC50=2µM); SARS(IC50=8.9µM) Vero |
| 10 |
ICV206 |
15.39 | 65.82% | 23.38% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(EC50=23µM) |
| 11 |
ICV145 |
15.25 | 67.28% | 22.67% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=24.14µM) |
| 12 |
ICV618 |
15.13 | 62.64% | 24.15% |
human: PIKfyve kinase | Q9Y2I7 | SARS-CoV-2(IC=10nM) Vero E6 |
| 13 |
ICV428 |
14.98 | 60.76% | 24.66% |
human: Eukaryotic initiation factor 4A-I | P60842 | MERS(EC50=3nM) MRC-5 cell; HCoV-229E(EC50=1.3nM) MRC-5 cell |
| 14 |
ICV275 |
14.89 | 67.11% | 22.18% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=6.2µM) |
| 15 |
ICV441 |
14.88 | 63.09% | 23.59% |
human: Tyrosine kinase | NA | MERS(EC50=2.9µM) Huh7 cell |
| 16 |
ICV290 |
14.69 | 65.98% | 22.27% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=9.1µM) |
| 17 |
ICV279 |
14.68 | 71.19% | 20.62% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=9.5µM) |
| 18 |
ICV280 |
14.66 | 70.38% | 20.83% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=9.2µM) |
| 19 |
ICV144 |
14.55 | 64.16% | 22.67% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=42.79µM) |
| 20 |
ICV400 |
14.53 | 61.35% | 23.68% |
virus: RNA-dependent RNA polymerase | P0DTD1 | polymerase extension experiments |
