| 1 |
ICV392 |
23.88 | 65.73% | 36.33% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=5.4µM) |
| 2 |
ICV284 |
22.71 | 70.76% | 32.09% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=10.4µM) |
| 3 |
ICV440 |
21.52 | 59.04% | 36.45% |
human: Synaptic Vesicular amine transporter | Q05940 | SARS(EC50=3.4µM) Vero E6 |
| 4 |
ICV442 |
21.26 | 65.81% | 32.3% |
human: 50S ribosomal protein L2 | P20276 | MERS(EC50=0.0718µM) Vero E6 |
| 5 |
ICV373 |
20.82 | 61.8% | 33.69% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=233.3µM); MERS PL(IC50=94.9µM) |
| 6 |
ICV280 |
20.44 | 65.55% | 31.18% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=9.2µM) |
| 7 |
ICV199 |
20.28 | 67.75% | 29.93% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=62.79µM) |
| 8 |
ICV285 |
20.28 | 62.45% | 32.47% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=13.9µM) |
| 9 |
ICV72 |
20.15 | 66.96% | 30.1% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=2.5µM) |
| 10 |
ICV374 |
19.58 | 63.73% | 30.71% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=92.4µM); MERS 3CL(IC50=125.7µM); MERS PL(IC50=49.1µM) |
| 11 |
ICV281 |
19.34 | 60.23% | 32.1% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=13.2µM) |
| 12 |
ICV282 |
19.17 | 59.06% | 32.46% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=12.7µM) |
| 13 |
ICV73 |
19.12 | 68.16% | 28.05% |
virus: 3C-like protease | P0DTD1 | Replicon (BHK) (IC50=2µM); SARS(IC50=8.9µM) Vero |
| 14 |
ICV372 |
18.98 | 59.95% | 31.66% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=84.8µM); MERS PL(IC50=88.5µM) |
| 15 |
ICV403 |
18.54 | 55.14% | 33.62% |
virus: Envelope protein; Spike protein | QHD43418.1,P0DTC2 | FIPV(EC50=7.8µM) Black TN406HP |
| 16 |
ICV376 |
18.39 | 63.07% | 29.17% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=64.2µM); MERS 3CL(IC50=109.2µM); MERS PL(IC50=55µM) |
| 17 |
ICV279 |
18.37 | 59.54% | 30.85% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=9.5µM) |
| 18 |
ICV617 |
18.34 | 68.34% | 26.84% |
human: Dihydroorotate dehydrogenase | Q02127 | SARS-CoV-2(EC50=1.96nM) Vero E6 |
| 19 |
ICV428 |
18.24 | 60.06% | 30.38% |
human: Eukaryotic initiation factor 4A-I | P60842 | MERS(EC50=3nM) MRC-5 cell; HCoV-229E(EC50=1.3nM) MRC-5 cell |
| 20 |
ICV200 |
18.04 | 59.91% | 30.11% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=101.38µM) |
