| 1 |
ICV392 |
22.39 | 61.4% | 36.46% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=5.4µM) |
| 2 |
ICV284 |
22.01 | 68.35% | 32.21% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=10.4µM) |
| 3 |
ICV440 |
21.55 | 58.25% | 36.99% |
human: Synaptic Vesicular amine transporter | Q05940 | SARS(EC50=3.4µM) Vero E6 |
| 4 |
ICV280 |
21.43 | 68.48% | 31.3% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=9.2µM) |
| 5 |
ICV72 |
20.98 | 69.48% | 30.19% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=2.5µM) |
| 6 |
ICV199 |
20.31 | 67.64% | 30.03% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=62.79µM) |
| 7 |
ICV202 |
20.27 | 66.69% | 30.39% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=90.72µM) |
| 8 |
ICV282 |
20.26 | 62.17% | 32.58% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=12.7µM) |
| 9 |
ICV285 |
20.18 | 61.91% | 32.59% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=13.9µM) |
| 10 |
ICV373 |
19.83 | 58.64% | 33.81% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=233.3µM); MERS PL(IC50=94.9µM) |
| 11 |
ICV200 |
19.36 | 63.34% | 30.57% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=101.38µM) |
| 12 |
ICV281 |
19.09 | 59.25% | 32.22% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=13.2µM) |
| 13 |
ICV442 |
19.02 | 59.45% | 31.99% |
human: 50S ribosomal protein L2 | P20276 | MERS(EC50=0.0718µM) Vero E6 |
| 14 |
ICV372 |
18.93 | 59.57% | 31.78% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=84.8µM); MERS PL(IC50=88.5µM) |
| 15 |
ICV428 |
18.91 | 62.04% | 30.48% |
human: Eukaryotic initiation factor 4A-I | P60842 | MERS(EC50=3nM) MRC-5 cell; HCoV-229E(EC50=1.3nM) MRC-5 cell |
| 16 |
ICV279 |
18.62 | 60.13% | 30.96% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=9.5µM) |
| 17 |
ICV276 |
18.5 | 65% | 28.46% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=6.1µM) |
| 18 |
ICV403 |
18.22 | 54.03% | 33.72% |
virus: Envelope protein; Spike protein | QHD43418.1,P0DTC2 | FIPV(EC50=7.8µM) Black TN406HP |
| 19 |
ICV413 |
18.22 | 64.07% | 28.43% |
human: Calcium channel | NA | MERS(IC=4.07µM) Vero |
| 20 |
ICV34 |
18.21 | 72.25% | 25.2% |
virus: 3C-like protease | P0DTD1 | MERS 3CL(IC50=9.6µM); SARS 3CL(IC50=18.7µM) |
