| 1 |
ICV392 |
23.04 | 61.59% | 37.41% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=5.4µM) |
| 2 |
ICV284 |
22.01 | 68.33% | 32.21% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=10.4µM) |
| 3 |
ICV280 |
21.38 | 68.33% | 31.3% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=9.2µM) |
| 4 |
ICV373 |
21.26 | 62.01% | 34.29% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=233.3µM); MERS PL(IC50=94.9µM) |
| 5 |
ICV440 |
20.83 | 57.63% | 36.14% |
human: Synaptic Vesicular amine transporter | Q05940 | SARS(EC50=3.4µM) Vero E6 |
| 6 |
ICV72 |
20.74 | 69.64% | 29.77% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=2.5µM) |
| 7 |
ICV282 |
20.18 | 61.92% | 32.58% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=12.7µM) |
| 8 |
ICV285 |
20.16 | 61.84% | 32.59% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=13.9µM) |
| 9 |
ICV199 |
20.07 | 67.8% | 29.61% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=62.79µM) |
| 10 |
ICV202 |
19.54 | 66.52% | 29.38% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=90.72µM) |
| 11 |
ICV428 |
19.22 | 62.13% | 30.93% |
human: Eukaryotic initiation factor 4A-I | P60842 | MERS(EC50=3nM) MRC-5 cell; HCoV-229E(EC50=1.3nM) MRC-5 cell |
| 12 |
ICV281 |
19 | 58.97% | 32.22% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=13.2µM) |
| 13 |
ICV372 |
18.95 | 59.61% | 31.78% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=84.8µM); MERS PL(IC50=88.5µM) |
| 14 |
ICV200 |
18.95 | 63.51% | 29.83% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=101.38µM) |
| 15 |
ICV390 |
18.67 | 65.79% | 28.38% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=7µM) |
| 16 |
ICV442 |
18.62 | 59.72% | 31.17% |
human: 50S ribosomal protein L2 | P20276 | MERS(EC50=0.0718µM) Vero E6 |
| 17 |
ICV279 |
18.61 | 60.1% | 30.96% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=9.5µM) |
| 18 |
ICV276 |
18.48 | 64.94% | 28.46% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=6.1µM) |
| 19 |
ICV413 |
18.23 | 64.11% | 28.43% |
human: Calcium channel | NA | MERS(IC=4.07µM) Vero |
| 20 |
ICV403 |
18.18 | 53.91% | 33.72% |
virus: Envelope protein; Spike protein | QHD43418.1,P0DTC2 | FIPV(EC50=7.8µM) Black TN406HP |
