| 1 |
ICV162 |
23.24 | 72.34% | 32.13% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=6.1µM) |
| 2 |
ICV206 |
19.59 | 75.1% | 26.09% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(EC50=23µM) |
| 3 |
ICV189 |
19.5 | 64.88% | 30.05% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=0.03µM) |
| 4 |
ICV374 |
18.95 | 75.81% | 25% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=92.4µM); MERS 3CL(IC50=125.7µM); MERS PL(IC50=49.1µM) |
| 5 |
ICV278 |
18.35 | 60.78% | 30.19% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=12.5µM) |
| 6 |
ICV282 |
17.93 | 62.9% | 28.51% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=12.7µM) |
| 7 |
ICV617 |
17.45 | 63.81% | 27.34% |
human: Dihydroorotate dehydrogenase | Q02127 | SARS-CoV-2(EC50=1.96nM) Vero E6 |
| 8 |
ICV303 |
17.31 | 72.87% | 23.76% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=13.5µM) |
| 9 |
ICV175 |
17.28 | 63.47% | 27.23% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=0.03µM) |
| 10 |
ICV161 |
17.17 | 55.75% | 30.8% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=10.6µM) |
| 11 |
ICV392 |
17.14 | 68.05% | 25.19% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=5.4µM) |
| 12 |
ICV285 |
16.98 | 59.45% | 28.57% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=13.9µM) |
| 13 |
ICV176 |
16.9 | 63.61% | 26.57% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=0.31µM) |
| 14 |
ICV191 |
16.85 | 66.07% | 25.51% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=13.5µM) |
| 15 |
ICV371 |
16.8 | 66.24% | 25.37% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=30.2µM); MERS 3CL(IC50=34.7µM); MERS PL(IC50=48.8µM) |
| 16 |
ICV435 |
16.64 | 72.19% | 23.05% |
human: MEK1,2 | NA | NA |
| 17 |
ICV277 |
16.61 | 55.3% | 30.05% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=11.6µM) |
| 18 |
ICV15 |
16.6 | 66.12% | 25.11% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=57µM) |
| 19 |
ICV158 |
16.4 | 71.14% | 23.05% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=6.8µM) |
| 20 |
ICV372 |
15.99 | 62.51% | 25.58% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=84.8µM); MERS PL(IC50=88.5µM) |
