| 1 |
ICV368 |
25.91 | 66.16% | 39.17% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=88.1µM); MERS 3CL(IC50=36.2µM); MERS PL(IC50=42.1µM) |
| 2 |
ICV377 |
25.51 | 59.17% | 43.12% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=61.9µM); MERS 3CL(IC50=33.9µM); MERS PL(IC50=82.2µM) |
| 3 |
ICV358 |
24.57 | 55.88% | 43.97% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=2.6µM); SARS(EC50=13.1µM) Vero E6; SARS-CoV-2(IC50=5µM) |
| 4 |
ICV333 |
24.1 | 68.01% | 35.43% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=0.39µM) |
| 5 |
ICV68 |
23.74 | 55.96% | 42.42% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=4.92µM); HCoV-229E 3CL(IC50=4.68µM) |
| 6 |
ICV158 |
23.19 | 56.74% | 40.86% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=6.8µM) |
| 7 |
ICV36 |
22.79 | 52.53% | 43.39% |
virus: 3C-like protease | P0DTD1 | MERS 3CL(IC50=6.7µM); SARS 3CL(IC50=10.9µM) |
| 8 |
ICV291 |
22.12 | 70.33% | 31.45% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=6.2µM) |
| 9 |
ICV355 |
21.96 | 76.01% | 28.89% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50<50µM) |
| 10 |
ICV160 |
21.95 | 53.3% | 41.18% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=5.5µM) |
| 11 |
ICV37 |
21.26 | 52.12% | 40.8% |
virus: 3C-like protease | P0DTD1 | MERS 3CL(IC50=15.7µM); SARS 3CL(IC50=9.7µM) |
| 12 |
ICV159 |
21.18 | 54.35% | 38.97% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=8.4µM) |
| 13 |
ICV332 |
20.98 | 66.6% | 31.5% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=5.7µM) |
| 14 |
ICV369 |
20.83 | 64.28% | 32.41% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=202.7µM); MERS 3CL(IC50=193.7µM); MERS PL(IC50=171.6µM) |
| 15 |
ICV28 |
20.63 | 64.4% | 32.03% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=44.7µM) |
| 16 |
ICV367 |
20.45 | 50.04% | 40.87% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=57.8µM); MERS 3CL(IC50=27.9µM); MERS PL(IC50=112.9µM) |
| 17 |
ICV32 |
19.82 | 62.05% | 31.95% |
virus: 3C-like protease | P0DTD1 | MERS 3CL(IC50=8.9µM); SARS 3CL(IC50=11.7µM) |
| 18 |
ICV29 |
19.62 | 64.53% | 30.4% |
virus: 3C-like protease | P0DTD1 | MERS 3CL(IC50=12.2µM); SARS 3CL(IC50=16.4µM) |
| 19 |
ICV35 |
19.55 | 65.09% | 30.04% |
virus: 3C-like protease | P0DTD1 | MERS 3CL(IC50=8.9µM); SARS 3CL(IC50=30.7µM) |
| 20 |
ICV27 |
19.4 | 61% | 31.8% |
virus: 3C-like protease | P0DTD1 | MERS 3CL(IC50=30.3µM); SARS 3CL(IC50=41.2µM) |
