| 1 |
ICV369 |
28.83 | 72.63% | 39.69% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=202.7µM); MERS 3CL(IC50=193.7µM); MERS PL(IC50=171.6µM) |
| 2 |
ICV377 |
28.02 | 72.45% | 38.68% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=61.9µM); MERS 3CL(IC50=33.9µM); MERS PL(IC50=82.2µM) |
| 3 |
ICV368 |
27.34 | 75.5% | 36.21% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=88.1µM); MERS 3CL(IC50=36.2µM); MERS PL(IC50=42.1µM) |
| 4 |
ICV291 |
23.98 | 75.82% | 31.62% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=6.2µM) |
| 5 |
ICV129 |
23.69 | 72.07% | 32.87% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(Ki=45.8µM) |
| 6 |
ICV130 |
22.74 | 73.56% | 30.92% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(Ki=35.3µM) |
| 7 |
ICV181 |
21.92 | 73.07% | 30% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=7µM) |
| 8 |
ICV18 |
21.06 | 57.58% | 36.59% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=43µM) |
| 9 |
ICV293 |
20.97 | 69.52% | 30.17% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=5.7µM) |
| 10 |
ICV154 |
20.88 | 55.29% | 37.76% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=25µM) |
| 11 |
ICV77 |
20.64 | 61.93% | 33.33% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=10µM); SARS(EC50=6.44µM) Vero E6 |
| 12 |
ICV73 |
19.99 | 70.15% | 28.49% |
virus: 3C-like protease | P0DTD1 | Replicon (BHK) (IC50=2µM); SARS(IC50=8.9µM) Vero |
| 13 |
ICV292 |
19.9 | 72.38% | 27.5% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=59.8µM) |
| 14 |
ICV427 |
19.79 | 67.38% | 29.37% |
human: Estrogen receptor | P03372 | MERS(EC50=12.915µM) Vero E6; SARS(EC50=11.969µM) Vero E6 |
| 15 |
ICV426 |
19.41 | 65.44% | 29.66% |
human: Estrogen receptor | P03372 | MERS(EC50=10.117µM) Vero E6; SARS(EC50=92.886µM) Vero E6 |
| 16 |
ICV57 |
19.39 | 59.26% | 32.72% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=1µM); SARS(ec50=0.18µM) Vero E6 |
| 17 |
ICV7(covalent) |
18.92 | 63.46% | 29.81% |
virus: 3C-like protease | P0DTD1 | MERS 3CL(IC50=1.7µM); SARS 3CL(IC50=0.2µM) |
| 18 |
ICV365 |
18.85 | 64.61% | 29.17% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS PL(IC50=30µM); SARS 3CL(IC50=21.1µM) |
| 19 |
ICV364 |
18.83 | 65.92% | 28.57% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS PL(IC50=4.9µM); SARS 3CL(IC50=14.4µM) |
| 20 |
ICV56 |
18.82 | 58.59% | 32.12% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=5µM); SARS(ec50=9.45µM) Vero E6 |
