| 1 |
ICV293 |
37.84 | 66.46% | 56.94% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=5.7µM) |
| 2 |
ICV377 |
35.53 | 85.49% | 41.56% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=61.9µM); MERS 3CL(IC50=33.9µM); MERS PL(IC50=82.2µM) |
| 3 |
ICV426 |
31.92 | 67.29% | 47.44% |
human: Estrogen receptor | P03372 | MERS(EC50=10.117µM) Vero E6; SARS(EC50=92.886µM) Vero E6 |
| 4 |
ICV368 |
30.67 | 71.56% | 42.86% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=88.1µM); MERS 3CL(IC50=36.2µM); MERS PL(IC50=42.1µM) |
| 5 |
ICV427 |
28.72 | 68.32% | 42.05% |
human: Estrogen receptor | P03372 | MERS(EC50=12.915µM) Vero E6; SARS(EC50=11.969µM) Vero E6 |
| 6 |
ICV291 |
28.1 | 65.04% | 43.21% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=6.2µM) |
| 7 |
ICV369 |
26.93 | 75.84% | 35.51% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=202.7µM); MERS 3CL(IC50=193.7µM); MERS PL(IC50=171.6µM) |
| 8 |
ICV154 |
23.39 | 67.31% | 34.75% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=25µM) |
| 9 |
ICV367 |
22.87 | 59.33% | 38.55% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=57.8µM); MERS 3CL(IC50=27.9µM); MERS PL(IC50=112.9µM) |
| 10 |
ICV303 |
22.03 | 69.48% | 31.71% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=13.5µM) |
| 11 |
ICV371 |
21.89 | 74.55% | 29.36% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=30.2µM); MERS 3CL(IC50=34.7µM); MERS PL(IC50=48.8µM) |
| 12 |
ICV391 |
21.21 | 73.47% | 28.87% |
virus: Helicase | P0DTD1 | SARS Helicase(IC50=2.7µM) |
| 13 |
ICV376 |
21.15 | 60.13% | 35.16% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=64.2µM); MERS 3CL(IC50=109.2µM); MERS PL(IC50=55µM) |
| 14 |
ICV302 |
20.92 | 68.63% | 30.49% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=90µM) |
| 15 |
ICV298 |
20.03 | 66.5% | 30.12% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=4.1µM) |
| 16 |
ICV408 |
19.53 | 64.05% | 30.49% |
human: ACE2 | P59594 | SARS(EC50=3µM) 293T |
| 17 |
ICV292 |
19.38 | 69.76% | 27.78% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=59.8µM) |
| 18 |
ICV438 |
19.25 | 66.37% | 29% |
human: Na channel | NA | MERS(IC=3.6µM) Vero |
| 19 |
ICV316 |
19.09 | 64.34% | 29.67% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=0.34µM); SARS(EC50=9.7µM) Vero E6 |
| 20 |
ICV375 |
19.02 | 64.38% | 29.55% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=43.3µM); MERS 3CL(IC50=135µM); MERS PL(IC50=39.5µM) |
