| 1 |
ICV146 |
28.17 | 64.77% | 43.5% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=32µM) |
| 2 |
ICV394 |
27.25 | 61.31% | 44.44% |
virus: Helicase | P0DTD1 | SARS nsP13 ATPase activity(IC50=0.86µM) |
| 3 |
ICV393 |
27.22 | 63.04% | 43.17% |
virus: Helicase | P0DTD1 | SARS nsP13 ATPase activity(IC50=2.71µM) |
| 4 |
ICV379 |
24.92 | 57.72% | 43.17% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=52.7µM); MERS 3CL(IC50=34.8µM) |
| 5 |
ICV148 |
24.87 | 57.25% | 43.43% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=72.3µM) |
| 6 |
ICV147 |
24.69 | 56.76% | 43.5% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=38.4µM) |
| 7 |
ICV378 |
24.68 | 56.01% | 44.07% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=116.3µM); MERS 3CL(IC50=35.3µM); MERS PL(IC50=206.6µM) |
| 8 |
ICV145 |
20.95 | 53.48% | 39.18% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=24.14µM) |
| 9 |
ICV370 |
20.77 | 53.95% | 38.5% |
virus: Papain-like protease; 3C-like protease | P0DTD1 | SARS 3CL(IC50=103.6µM); MERS 3CL(IC50=64.5µM); MERS PL(IC50=112.5µM) |
| 10 |
ICV388 |
20.15 | 60.95% | 33.06% |
virus: Helicase | P0DTD1 | SARS(EC50=6µM) |
| 11 |
ICV356 |
19.91 | 59.1% | 33.68% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50<50µM) |
| 12 |
ICV323 |
17.6 | 69.04% | 25.49% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=32µM) |
| 13 |
ICV440 |
17.39 | 64.19% | 27.08% |
human: Synaptic Vesicular amine transporter | Q05940 | SARS(EC50=3.4µM) Vero E6 |
| 14 |
ICV280 |
17.16 | 71.34% | 24.05% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=9.2µM) |
| 15 |
ICV281 |
16.94 | 71.14% | 23.81% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=13.2µM) |
| 16 |
ICV144 |
16.8 | 42.88% | 39.18% |
virus: 3C-like protease | P0DTD1 | SARS 3CL(IC50=42.79µM) |
| 17 |
ICV276 |
16.6 | 68.61% | 24.2% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=6.1µM) |
| 18 |
ICV346 |
16.32 | 69.93% | 23.33% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=0.35µM) |
| 19 |
ICV299 |
16.22 | 65.16% | 24.89% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=5µM) |
| 20 |
ICV275 |
15.84 | 65.14% | 24.31% |
virus: Papain-like protease | P0DTD1 | SARS PL(IC50=6.2µM) |
